Zebrafish are vertebrates often used for in vivo studies, because they are relatively small in size and the embryonic and larval development is ex utero and fast, since within 5 days post-fertilization (dpf), all major organ systems are formed (Kimmel et al., 1995). The genetic underpinnings of heart development in zebrafish are highly similar to that in humans, while zebrafish presents many advantages that allow for rapid screening of candidate CHD-associated gene variants. Rajesh Pamanji, Zebrafish Model System in Antimicrobial Drug Discovery, Model Organisms for Microbial … Zebrafish is a relatively new model organism, new kid on the block, if you will. The use o f zebrafish as a model organism got impetus from the 1990s when . The model organism zebrafish in imaging-based analysis. Reverse genetics has not been worked out for zebrafish as it has in the mouse. Simmons, Hannah. Furthermore, their genome is fully sequenced and easily accessible via the Zebrafish Model Organism Database (ZFIN; https://zfin.org), which provides researchers with a repository of genetic, genomic, and phenotypic data. Zebrafish cancer models. It is in the interest of every biological investigation to capture molecular dynamics within the context of a physiologically relevant environment. The zebrafish is particularly well suited for this research due to its small size, rapid development, short generation time, optical transparency of embryos and larvae as well as functional conservation of genes [ 1 ]. 2c). Several models of cancer have been generated in zebrafish. High Volume of Background Information. The zebrafish (Danio rerio) is a freshwater fish belonging to the minnow family of the order Cypriniformes.Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (and thus often called a "tropical fish" although both tropical and subtropical).. Areas covered: The authors discuss the advantages and disadvantages of the zebrafish xenograft model for the study of cancer, metastasis and drug discovery. Zebrafish, a freshwater tropical fish, is a premiere model organism to study vertebrate development. Genetics of Zebrafish 5. Department of Zoology Roll number -15 ZOO 016 Utkal University, Vani Vihar Bhubaneswar- 751 004. But how do zebrafish compare to other popular organism models? ZEBRAFISH: AS A MODEL ORGANISM PRESENTED BY GUIDED BY Namrata Singh Prof. (Mrs) Pravati Kumari Mahapatra M.Sc. Plus a few others depending on your area of research (i.e. The zebrafish Danio rerio has become an important vertebrate model organism for a wide range of scientific research questions including development, genetics, and disease . A model organism is one which is studied to further our understanding of biological processes. Scientists study model organisms to understand how human diseases work. At first, zebrafish were increasingly used by developmental biologists. The use of zebrafish as a model organism was pioneered to overcome some of the difficulties that plague other vertebrate model organisms such as in utero development, low offspring number, lack of genetic tractability, and high maintenance costs. Crossref. Zebrafish-embryo assays can also help to predict drug safety in human. Zebrafish is emerging as a model organism of choice to understand the etiology of human CHD. Adult zebrafish are small in size, they grow quickly, and they breed readily. Disadvantages: They require water systems to maintain them; They are not mammals and are not as closely related to humans as a mouse is. The use of the zebrafish to study vertebrate developmental biology began with George Streisinger at the University of Oregon in the late 1960s. While mice have a distinct advantage being mammals, zebrafish possess a number of beneficial traits. Advantages and Disadvantages of Zebrafish Compared to Other Model Organisms for the Study of the Neural Basis of Behavior What is a Model Organism in the Context of Systems Neuroscience? Accessibility. ... all of these factors make them a very cheap and useful model organism. Zebrafish . Besides being more affordable and efficient, these little fish also develop externally. Zebrafish as a model organism for studies of vertebrate embryogensis. Zebrafish entered the field at a time when many molecular biology techniques including mutagenesis and cloning of genes had already been … Zebrafish (Danio rerio) are a small‐bodied tropical, freshwater fish species originally from South Asia. Here, we define the characteristics that a fish species should have to serve as a model for finfish aquaculture research and argue that the zebrafish fulfils essentially most of them. Introduction 2. It came into awareness in the scientific community, at least for geneticists, roughly around 1981 when the late George Streisinger, looking for a new genetic organism to study, picked up a couple of zebrafish at the local pet store and started to do a few experiments with them. The early career of the zebrafish. Fast external development and transparency during embryogenesis allow for visual screening at the macroscopical and microscopical level, including visualization of organogenesis. an ecologist will look at different characteristics and criteria that a geneticist). Danio rerio (zebrafish) is an excellent model organism for CNV studies. In mice, for example, you can "knock … The general suitability of zebrafish as a model organism, as well as its use in the genetic and neuroanatomical analysis of larval behaviour has been comprehensively described elsewhere [1, 2]. Zebrafish genome contains numerous duplicate genes (Milan DJ et al, 2003) and this feature often hinders the generation of knockout strains, as approaches that disrupt one gene copy likely will not disrupt the second copy. Zebrafish, or Danio rerio, are a model organism as they have a number of key traits that make them useful to study: Transparent embryos that allow us to easily track stages of development. 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